Lopez stars in and executive produces his multi-camera comedy series for NBC, Lopez vs Lopez, featuring his real-life daughter, Mayan Lopez. The family sitcom, recently renewed for its third season, stars father and daughter in a fictionalized version of their real-life relationship, exploring dysfunction, reconnection, and all the pain and joy in between. Lopez als0 joined the DC Extended Universe, starring in the Warner Bros. Latin superhero film, Blue Beetle. Directed by Angel Manuel Soto and featuring a predominantly Latino cast, the film follows its first ever Mexican American teenager turned superhero.
The movie received nominations for Best Superhero Film at the 2024 Saturn Awards and for Best Superhero Movie at the 2024 Critics Choice Super Awards. Lopez can also be seen in Snoop Dogg’s Amazon MGM sports comedy, The Underdoggs, and in the independent holiday comedy How the Gringo Stole Christmas, directed by Angel Gracia. Lopez released the third installment of his middle-grade novel series, Chupacarter and the Screaming Sombrero last March. He is currently performing stand-up across the country on his Comedy Tour.
Lopez has four HBO specials: The Wall (2017), It’s Not Me, It’s You (2012), Tall, Dark and Chicano (2009), which was nominated for a Best Comedy Album Grammy Award, and America's Mexican (2007). His acclaimed comedy concert, Why You Crying?, debuted on Showtime in 2004. He released his third stand-up CD, El Mas Chingon, in 2006, earning another Grammy nomination. In 2004, he was nominated for his first Grammy in the same category for Team Leader.